Derivatives of dimethylcurcumin

A compound of Formula I:

• or a pharmaceutically acceptable salt thereof or a tautomer thereof,
• wherein:
• R1, R2, R3 and R4 are each independently selected from the group consisting of —OH, —O(C1-C6 alkyl), —NO2, —NH2, —NH(C1-C6 alkyl) and —N(C1-C6 alkyl)2, wherein each C1-C6 alkyl is optionally and independently substituted with one or more deuterium;
• R5 and R6 are each independently hydrogen, deuterium, halo, or —NO2;
• R7 is hydrogen, deuterium, or —R13;
• R13 is (C2-C6) alkenyl optionally substituted with one or more deuterium and substituted with —C(O)R12;
• R12 is —OCH3, —OCH2CH3, —NH(CH2CH3), —CN, or —CH2OH, wherein each of —OCH3, —OCH2CH3, —NH(CH2CH3), and —CH2OH is optionally substituted with one or more deuterium;
• R8 and R11 are each independently hydrogen or deuterium;
• R9 and R10 are each independently hydrogen or deuterium;
• X1 and X2 are each independently N, CH, CD, C(OCH3), C(OCD3) or C(NO2);
• provided that at least one of R1, R2, R3, R5, R6, R7, R8, R10, X1 and X2 comprises deuterium;
• and provided that the compound of Formula I is not