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US 2011/0257245 A1Published application
Methods of identifying regulators of cellular proteostasis
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorRon R. Kopito
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Abstract
Embodiments of the present invention provide methods for identifying and utilizing regulators of cellular proteostasis as new therapeutic targets against protein misfolding diseases.
Claims10
A method of identifying a regulator of cellular protein homeostasis, the method comprising:
- providing a cell expressing a ubiquitin-proteasome system (UPS) reporter and an aggregation-prone protein;
- contacting said cell with a candidate agent;
- and
- analyzing said UPS reporter expression in presence of said candidate agent;
- comparing said UPS reporter expression in presence of said candidate agent with UPS reporter expression in absence of said candidate expression;
- and
- assessing said candidate agent's potential as regulator of cellular protein homeostasis.
4 more elements
Dependencies are inferred from the claim text.