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US 2011/0257244 A1Published application
Chemically modified oligonucleotides and small molecules for use in reducing micro rna activity levels and uses thereof
AssigneeAlnylam Pharmaceuticals, Inc.
InventorsMuthiah Manoharan, Kallanthottathil G. Rajeev
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Abstract
This invention relates generally to chemically modified oligonucleotides useful for modulating activity of microRNAs and pre-microRNAs. More particularly, the invention relates to single stranded chemically modified oligonucleotides for inhibiting microRNA and pre-microRNA activity and to methods of making and using the modified oligonucleotides.
Claims1
A method of reducing the amount of a microRNA activity in a cell in a subject comprising the step of administering antagomir 3631 to the subject.
Dependencies are inferred from the claim text.