Back to results
US 2011/0257243 A1Published application
3-phenoxymethylpyrrolidine compounds
AssigneeTheravance, Inc.
InventorsEric Stangeland, Daisuke Roland Saito, Adam Hughes, Jane Schmidt, Priscilla Van Dyke, Lori Jean Patterson
Life of this patent
Estimating the term…
Abstract
In one aspect, the invention relates to compounds of formula I: where R1-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Claims31
A compound of formula I:
- where:
- R1 is selected from —C2-6alkyl, —C3-8cycloalkyl optionally substituted with 1 or 2 fluoro atoms, —C2-6alkenyl, and —C2-6alkynyl;
- R2 through R6 are independently selected from hydrogen, halo, —C1-6alkyl, —CF3, —O—C1-6alkyl, —CN, —C(O)—C1-6alkyl, —S—C1-6alkyl, —C3-8cycloalkyl, and —NO2;
- or R4 and R5 are taken together to form —CH═CH—CH═CH—;
- or R5 and R6 are taken together to form —CH—CH═CH—CH—;
- with the proviso that when R1 is ethyl, R2 is fluoro, R4 is chloro, R5 is hydrogen, and R6 is hydrogen, then R3 is not fluoro or chloro;
- or a pharmaceutically acceptable salt thereof.
4 more elements
Dependencies are inferred from the claim text.