Sustained release pharmaceutical composition and method of releasing pharmaceutically active agent
OwnerRajen Shah, Arun Parmanand Patel +1inventors
InventorsRajen Shah, Arun Parmanand Patel, Roy Thomas Sandry
Life of this patent
Estimating the term…
Abstract
The present invention is directed to solid, sustained-release, oral dosage form pharmaceutical compositions which contain therapeutic amounts of a pharmaceutically active agent, hydroxypropyl methyl cellulose and a non-ionic, hydrophilic polymer selected froth the group consisting of hydroxyethyl cellulose having a number average molecular weight ranging from 90,000 to 1,300,000, hydroxypropyl cellulose having a number average molecular weight of 370,000 to 1,500,000, and poly(ethylene oxide) having a number average molecular weight ranging from 100,000 to 500,000.
Claims21
1-15. (canceled)
A sustained release pharmaceutical composition comprising:
- a drug substance component selected from the group consisting of fluvastatin and pharmaceutically acceptable salts thereof,
- a hydroxypropyl methyl cellulose component consisting of a hydroxypropyl methyl cellulose with a number average molecular weight between about 20,000 and 30,000 and
- a nonionic, hydrophilic polymer component selected from the group consisting of hydroxyethyl cellulose having a number average molecular weight ranging from 90,000 to 1,300,000, hydroxypropyl cellulose having a number average molecular weight of 370,000 to 1,500,000 and poly(ethylene oxide) having a number average molecular weight ranging from 100,000 to 500,000.
A sustained release pharmaceutical tablet comprising:
- a lubricant and
- a granulation comprising
- the drug substance component selected from the group consisting of fluvastatin and pharmaceutically acceptable salts thereof,
- a hydroxypropyl methyl cellulose component consisting of a hydroxypropyl methyl cellulose with a number average molecular weight between about 20,000 and 30,000 and
- a nonionic, hydrophilic polymer component selected from the group consisting of hydroxyethyl cellulose having a number average molecular weight ranging from 90,000 to 1,300,000, hydroxypropyl cellulose having a number average molecular weight of 370,000 to 1,500,000 and poly(ethylene oxide) having a number average molecular weight ranging from 100,000 to 500,000.
Dependencies are inferred from the claim text.