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US 2011/0257212 A1Published application
New azacyclic derivatives
AssigneeHoffmann-La Roche Inc.
InventorsJean Ackermann, Aurelia Conte, Daniel Hunziker, Werner Neidhart, Matthias Nettekoven, Tanja Schulz-Gasch, Stanley Wertheimer
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Abstract
The invention provides novel compounds having the general formula (I) wherein R1, R2 and A are as described herein, compositions including the compounds and methods of using the compounds. The compounds inhibit hormone sensitive lipase (HSL) and may be used in the treatment of diabetes, metabolic syndrome, and obesity.
Claims13
A compound of formula (I)
- wherein
- R1 is selected from the group consisting of:
- alkyl, cycloalkyl, haloalkyl, piperidinyl, piperazinyl, morpholinyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, oxazolyl, isoxazolyl, thiazolyl, phenyl, pyridinyl, pyrazinyl, pyrimidyl and pyridazinyl, wherein said piperidinyl, piperazinyl, morpholinyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, oxazolyl, isoxazolyl, thiazolyl, phenyl, pyridinyl, pyrazinyl, pyrimidyl and pyridazinyl may be substituted with one to three substituents independently selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, halogen, haloalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, haloalkoxy and hydroxyhaloalkyl;
- R2 is selected from the group consisting of:
- phenyl, pyridinyl, pyrazinyl, pyrimidyl and pyridazinyl,
- wherein said phenyl, pyridinyl, pyrazinyl, pyrimidyl and pyridazinyl may be substituted with one to three substituents independently selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, halogen, haloalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, haloalkoxy and hydroxyhaloalkyl;
- A is selected from the group consisting of:
- —(CH2)n—, —C(O)— and —S(O)2—;
- and
- n is zero, 1 or 2;
- or a pharmaceutically acceptable salt thereof.
8 more elements
Dependencies are inferred from the claim text.