Compounds useful as faah modulators and uses thereof

A compound having a formula:

• wherein
• each A and B is independently CR2aR2b;
• W and Z are independently N or CR4;
• L1 is a single bond or substituted or unsubstituted C1-C5 alkylene, —CO—, —NHC(O)—, —OC(O)—, —SO—, or S(O)2—;
• R1 is selected from a substituted or unsubstituted aryl or heteroaryl;
• each of R2a, and R2b is independently selected from hydrogen, and substituted or unsubstituted C1-C6 alkyl;
• R3 is selected from substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C3-C8cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl;
• and
• R4 is independently selected from H, C1-C6alkyl, substituted C1-C6alkyl, acyl, substituted acyl, substituted or unsubstituted acylamino, substituted or unsubstituted amino, substituted or unsubstituted alkoxy, alkoxycarbonyl, substituted alkoxycarbonyl arylalkyloxy, substituted arylalkyloxy, amino, aryl, substituted aryl, arylalkyl, substituted arylalkyl, substituted sulfanyl, substituted sulfinyl, substituted sulfonyl, substituted or unsubstituted aminosulfonyl, sulfo, sulfonic acid ester, azido, carboxy, substituted or unsubstituted carbamoyl, cyano, substituted or unsubstituted C3-C8cycloalkyl, substituted or unsubstituted heterocycloalkyl, halo, heteroaryloxy, substituted or unsubstituted heteroaryl, hydroxy, nitro, and thiol;
• or a pharmaceutically acceptable salt, solvate or prodrug thereof;
• and stereoisomers, isotopic variants and tautomers thereof;
• provided that the compound is other than
• N-[5-(1,1-dimethylethyl)-2-methylphenyl]-6,7-dihydro-2-[4-(4-methoxyphenyl)-1-piperazinyl]-6-(methylsulfonyl)-5H-pyrrolo[3,4-d]pyrimidin-4-amine;
• 4-[[5-(1,1-dimethylethyl)-2-methylphenyl]amino]-5,7-dihydro-2-[4-(4-methoxyphenyl)-1-piperazinyl]-6H-Pyrrolo[3,4-d]pyrimidine-6-carboxylic acid, 1,1-dimethylethyl ester;
• 2-chloro-4-[[3-(dimethylamino)-5-methoxyphenyl]amino]-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid, 9H-fluoren-9-ylmethyl ester;
• 2-chloro-5,7-dihydro-4-[(5-methyl-1H-pyrazol-3-yl)amino]-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid, 9H-fluoren-9-ylmethyl ester;
• and
• N-(2,3-dihydro-1H-inden-2-yl)-6,7-dihydro-2-(methylthio)-6-(phenylmethyl)-5H-pyrrolo[3,4-d]pyrimidin-4-amine.