Therapeutic Compositions and Methods for Treating Chronic Kidney Disease Associated with a Metabolic Imbalance
OwnerRichard J Johnson, Takahiko Nakagawainventors
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Abstract
Disclosed herein are compositions and methods for treating chronic kidney disease and/or a metabolic imbalance. Specifically exemplified herein are methods involving the coadministration of a RAS inhibitor with a conjunctive agent that improves endothelial NO or endothelial function. Also disclosed are methods of treating a patient exhibiting symptoms of a stage of chronic kidney disease and at least one symptom of a metabolic imbalance, such as one or more diagnostic criteria of the metabolic syndrome.
Claims25
A therapeutic composition useful for treating chronic kidney disease in a patient exhibiting at least one symptom of a metabolic imbalance, said composition comprising a RAS inhibitor and a NO mimetic.
A method of treating chronic kidney disease in a patient exhibiting at least one symptom of a metabolic imbalance, the method comprising coadministering a therapeutically effective amount of a RAS inhibitor and a conjunctive agent.
A method of treating chronic kidney disease in a patient exhibiting at least one symptom of a metabolic imbalance, said method comprising administering a therapeutically effective amount of nicorandil.
A composition useful for treating diabetic nephropathy comprising a therapeutically effective amount of a RAS inhibitor and a uric acid lowering agent or antioxidant, or a combination of a uric acid lowering agent and antioxidant.
Dependencies are inferred from the claim text.