Reverse-turn mimetics and method relating thereto

A compound having the following formula (VII)

• —R10 (VI)
• wherein (VI) is the formula:
• wherein,
• Ra is a phenyl group;
• a substituted phenyl group having one or more substituents wherein the one or more substituents are independently selected from one or more of amino, amidino, guanidino, hydrazino, amidazonyl, C1-4alkylamino, C1-4dialkylamino, halogen, perfluoro C1-4alkyl, C1-4alkyl, C1-3alkoxy, nitro, carboxy, cyano, sulfuryl, and hydroxyl groups;
• or a bicyclic aryl group having 8 to 11 ring members, which may have 1 to 3 heteroatoms selected from nitrogen, oxygen and sulfur;
• Rb is a monocyclic aryl group having 5 to 7 ring members, which may have 1 to 2 heteroatoms selected from nitrogen, oxygen or sulfur, and aryl ring in the compound may have one or more substituents selected from a group consisting of halogen, hydroxy, cyano, lower alkyl, and lower alkoxy groups;
• Rc is a saturated or unsaturated C1-6alkyl, C1-6alkoxy, perfluoro C1-6alkyl group;
• and
• X1, X2, and X3 may be the same or different and independently selected from hydrogen, hydroxyl, and halide;
• and
• wherein one of Ra, Rb, Rc, X1, X2, and X3 is linked to R10 via Y,
• Y is (a) an oxygen, sulfur, or nitrogen atom in Ra, Rb, and Rc, or (b) an oxygen atom in X1, X2 and X3, when X1, X2 or X3 is hydroxyl;
• and
• Y—R10 is phosphate, hemisuccinate, dimethylaminoacetate, an amino acid residue, or a salt thereof;
• or R10 is phosphoryloxymethyloxycarbonyl, or a salt thereof.