Pyridazinone derivatives

Compounds of the formula I

• in which
• R1 denotes Ar, Het, A, OR2, O[C(R2)2]nAr, O[C(R2)2]nHet, N(R2)2, NR2[C(R2)2]nAr or NR2[C(R2)2]nHet,
• R2 denotes H or A′,
• R3, R3′ each, independently of one another, denote H, Hal, A, OR2, CN, COOR2, CON(R2)2, NR2COA, NR2SO2A, SO2N(R2)2 or S(O)mA,
• Y denotes [C(R2)2]nNR2COZ, [C(R2)2]nNR2COHet1, [C(R2)2]nCyc[C(R2)2]nN(R2)2, [C(R2)2]nCyc[C(R2)2]nOR2, [C(R2)2]nCyc[C(R2)2]nHet1,
• [C(R2)2]nHet2, [C(R2)2]nCR2(NR2)2COOR2, [C(R2)2]nNR2CO[C(R2)2]nNR2COA, [C(R2)2]nNR2COOA, [C(R2)2]nCO—NR2-A, [C(R2)2]nCO—NR2—[C(R2)2]nHet1, [C(R2)2]nCONH2, [C(R2)2]nCONHA, [C(R2)2]nCONA2, [C(R2)2]nCO—NR2—[C(R2)2]nN(R2)2 or COOA,
• Z denotes CR2(NR2)2CR2(OR2)A,
• Ar denotes phenyl, naphthyl or biphenyl, each of which is unsubstituted or mono-, di- or trisubstituted by Hal, A, [C(R2)2]nOR2, [C(R2)2]nN(R2)2, SR2, NO2, CN, COOR2, CON(R2)2, NR2COA, NR2SO2A, SO2N(R2)2, S(O)mA, CO-Het, Het, O[C(R2)2]nN(R2)2, O[C(R2)2]nHet, NHCOOA, NHCON(R2)2, NHCOO[C(R2)2]nN(R2)2, NHCOO[C(R2)2]nHet, NHCONH[C(R2)2]nN(R2)2, NHCONH[C(R2)2]nHet, OCONH[C(R2)2]nN(R2)2, OCONH[C(R2)2]nHet, CONR2[C(R2)2]nN(R2)2, CONR2[C(R2)2]nHet and/or COA,
• Het denotes a mono-, bi- or tricyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which may be unsubstituted or mono-, di- or trisubstituted by Hal, A, [C(R2)2]nOR2, [C(R2)2]nN(R2)2, SR2, NO2, CN, COOR2, CON(R2)2, NR2COA, NR2SO2A, SO2N(R3)2, S(O)mA, CO-Het1, [C(R2)2]nHet1, O[C(R2)2]nN(R2)2, O[C(R2)2]nHet1, NHCOOA, NHCON(R2)2, NHCOO[C(R2)2]nN(R2)2, NHCOO[C(R2)2]nHet1, NHCONH[C(R2)2]nN(R2)2, NHCONH[C(R2)2]nHet1, OCONH[C(R2)2]nN(R2)2, OCONH[C(R2)2]nHet1, CO-Het1, CHO, COA, ═S, ═NH, ═NA and/or ═O (carbonyl oxygen),
• Het1 denotes a monocyclic saturated heterocycle having 1 to 2 N and/or O atoms, which may be mono- or disubstituted by A, OA, OH, COOH, COOA, Hal and/or ═O (carbonyl oxygen),
• Het2 denotes 2-methoxycarbonylpyrrolidin-4-yl, 2-carboxypyrrolidin-4-yl, 1-cyclopropylmethylpiperidin-4-yl, piperidin-4-yl, morpholin-2- or 4-yl, 1-isopropylpiperidin-4-yl, 1-methylpiperidin-4-yl, 4-piperazinyl, 1-methylpyrrolidin-2-yl, 1-tert-1-butoxycarbonylpiperidin-4-yl, 1-ethylpiperidin-2-yl, 1-(2-methoxyethyl)piperidin-4-yl, 1-[2-(N,N-dimethylamino)ethyl]-piperidin-4-yl, 1,2,2,6,6-pentamethylpiperidin-4-yl, 1-azabicyclo[2.2.2]oct-3-yl, tetrahydropyran-4-yl, 1-formylpiperidin-4-yl or 1-methyl-1-oxypiperidin-4-yl,
• A denotes unbranched or branched alkyl having 1-10 C atoms, in which 1-7 H atoms may be replaced by F and/or in which one or two non-adjacent CH2 groups may be replaced by O, NH, S, SO, SO2 and/or by CH═CH groups,
• or
• cyclic alkyl having 3-7 C atoms,
• A′ denotes unbranched or branched alkyl having 1-6 C atoms, in which 1-5 H atoms may be replaced by F,
• Cyc denotes cycloalkylene having 3-7 C atoms,
• Hal denotes F, Cl, Br or I,
• m denotes 0, 1 or 2,
• n denotes 0, 1, 2, 3 or 4,
• p denotes 1, 2, 3, 4 or 5,
• and pharmaceutically usable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios.