Biomarkers of Mineralocorticoid Receptor Activation
AssigneeInserm (Institut National De La Sante Et De La Rec Herche Medicale)
InventorsFrederic Jaisser, Nicolette Farman, Yannis Sainte-Marie, Celine Latouche, Marja Steenman
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Abstract
The present invention relates to the use of Neutrophil Gelatinase-Associated Lipocalin (NGAL) and/or SERPINA3 as biomarkers of the Mineralocorticoid Receptor (MR) activation in a patient. More particularly, the present invention relates to a method for predicting the responsiveness of a patient to a treatment with a MR antagonist or an aldosterone synthase inhibitor, said method comprising determining in a biological sample obtained from said patient the expression level of the NGAL gene and/or of the SERPINA3 gene.
Claims20
A method for assessing the Mineralocorticoid Receptor (MR) activation in a patient comprising determining in a biological sample obtained from said patient the expression level of one or two biomarkers selected from the group consisting of the Neutrophil Gelatinase-Associated Lipocalin (NGAL) gene and the SERPINA3 gene.
2-15. (canceled)
A method for predicting the responsiveness of a patient to a treatment with a MR antagonist or an aldosterone synthase inhibitor, said method comprising determining in a biological sample obtained from said patient the expression level of one or two biomarkers selected from the group consisting of the Neutrophil Gelatinase-Associated Lipocalin (NGAL) gene and the SERPINA3 gene.
A method for treating a patient affected with a cardiovascular disease, diabetes, obesity or metabolic syndrome, comprising the step of administering to said patient a MR antagonist or an aldosterone synthase inhibitor, wherein said patient has an expression level of one or two biomarkers selected from the group consisting of the Neutrophil Gelatinase-Associated Lipocalin (NGAL) gene and the SERPINA3 gene, higher than a predetermined value obtained from the general population or from healthy subjects.
A kit comprising:
- a) means for detecting the NGAL protein;
- and
- b) means for detecting the SERPINA3 protein.
Dependencies are inferred from the claim text.