Microcirculation improvement and/or treatment

A method of improving microcirculation in a subject suffering from diabetes comprising administering to the subject a composition comprising an effective amount of at least one agent selected from the group consisting of epicatechin, catechin, polymeric compound having the formula An and a derivative or a pharmaceutically acceptable salt of each:

• wherein
• R and X each have either α or β stereochemistry;
• R is OH;
• the substituents of C-4, C-6 and C-8 are X, Z and Y, respectively, and bonding of monomeric units occurs at C-4, C-6 or C-8;
• when any C-4, C-6 or C-8 is not bonded to another monomeric unit, X, Y and Z are hydrogen or a sugar;
• the sugar is optionally substituted with a phenolic moiety.

A method of dietary management of a diabetes-associated condition comprising administering to a human subject a composition comprising an effective amount of at least one agent selected from the group consisting of epicatechin, catechin, polymeric compound having the formula An wherein n is 2 to 10;

• and a pharmaceutically acceptable salt or derivative of each:
• wherein
• R and X each have either α or β stereochemistry;
• R is OH;
• the substituents of C-4, C-6 and C-8 are X, Z and Y, respectively, and bonding of monomeric units occurs at C-4, C-6 or C-8;
• when any C-4, C-6 or C-8 is not bonded to another monomeric unit, X, Y and Z are hydrogen or a sugar;
• the sugar is optionally substituted with a phenolic moiety.