Isolated compounds from phaleria macrocarpa as anti-cancer agents
AssigneePt. Dexa Medica
InventorsAsep Aripin, Poppy Firzani Arifin, Raymond R. Tjandrawinata
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Abstract
The invention concerns compounds DLBS1425E2.2 and DLBS1425F1 isolated and identified from the extract of the plant Phaleria macrocarpa (Scheff.) Boerl. The invention also relates to the use of said compounds, either as a single active compound or in combination, in a pharmaceutical dosage form that has anti-proliferative activity of cancer cells, and its use relating to female related diseases. Formula (I).
Claims11
A pure compound having a basic structure of benzophenone, diphenylmethanone, diphenylketone, or benzoylbenzene with 3 hydroxyl groups (—OH) substituted at carbon 2, 6, and 4′;
- methoxy group (—OCH3) substituted at carbon 4.
1 A pure compound having a basic structure of benzophenone, diphenylmethanone, diphenylketone, or benzoylbenzene with 2 hydroyl groups (—OH) substituted at carbon 4′ and 6;
- a methoxy group (—OCH3) substituted at carbon 4, and β-D-glycopyranoside substituted at carbon 2.
The pure compound according to claim 6, wherein such compound has relative molecular mass of 422.6 g/mol.
The pure compound according to claim 6, wherein such compound has hydroxyl group (binding to C aromatic), hydroxyl group (binding to C aliphatic), carbonyl group, O-ether group, conjugated carbon bond, and hydrogen-carbon aliphatic single bond, respectively.
The pure compound according to claim 6, wherein NMR experiment, its hydrogen atoms of such compound show chemical shift at (δ):
- 6.2;
- 6.4;
- 6.8;
- 7.7;
- δ 6.2 (1H, d, JHz=1.85);
- δ 6.4 (1H, d, JHz=1.85);
- δ 6.8 (2H, d, JHz=8.5) dan δ 7.7 (2H, d, JHz=8.5);
- δ 3.8 (1H, s), δ 4.8 (2H, d, JHz=7.9).
The pure compound according to claim 6;
- wherein NMR experiment, its carbon atoms of such compound show chemical shift at δ=164.3;
- 164.10;
- 159.03;
- 158.51;
- 133.69;
- 131.84;
- 116.04;
- 111.77;
- 102.55;
- 96.80;
- 94.90;
- 78.41;
- 77.91;
- 4.83;
- 71.31;
- 62.65;
- 56.01;
- and δ 192.5 (C═O).
The use of Phaleria macrocarpa (Scheff.) Boerl. extract including E2.2 and/or F1 compound(s) which derived there from to make pharmaceutical dosage forms as anti proliferation of cancer cells, apoptosis inducer, anti cancer, also diseases related to neoplasia and treatment for female related diseases or other gynecologic diseases such as cancer, adenoma, cyst related to breast, uterus, cervical, and ovary.
Dependencies are inferred from the claim text.