Compositions and methods of treating cancer
AssigneeCase Western Reserve University
InventorsMan-Sun Sy, Wei Xin, Chaoyang Li, Shuiliang Yi, Shaoman Yin
Life of this patent
Estimating the term…
Abstract
A method of inhibiting neoplastic, cancer, and/or tumorgenic cell proliferation, cell growth and motility in a subject includes administering to a cancer cell expressing Pro-PrP and FLNa a therapeutically effective amount of a Pro-PrP regulating agent.
Claims25
A method of inhibiting adhesion, motility, migration, dispersal, and/or metastasis of a neoplastic, cancer, and/or tumorgenic cell in a subject, the cell expressing pro-prion protein (pro-PrP) and filamin A (FLNa), the method comprising:
- administering to the cell a therapeutically effective amount of a pro-PrP regulating agent.
A pharmaceutical composition for inhibiting adhesion, motility, migration, dispersal, and/or metastasis of a cancer cell expressing pro-PrP and FLNa, comprising a peptide consisting of about 5 to about 15 amino acids that are substantially homologous to consecutive amino acids of the amino acid sequence of the GPI-PSS domain of pro-PrP.
A method of treating a cancer in a subject, the cancer including cancer cells that express pro-PrP and FLNa, comprising:
- administering to the cancer cells a therapeutically effective amount of a pro-PrP regulating agent.
A method of detecting cancer or an increased likelihood of cancer in a subject comprising;
- obtaining a bodily sample from the subject;
- detecting a level of pro-PrP in the sample;
- and
- correlating the level of pro-PrP in the sample to presence or increased likelihood of cancer in the subject.
Dependencies are inferred from the claim text.