Crystal Forms of Saxagliptin and Processes for Preparing Same

A method for treating diabetes, insulin resistance, hyperglycemia, hyperiulinemia, dyslipidemia or elevated blood levels of free fatty acids or glycerol, obesity, Syndrome X, dysmetabolic syndrome, diabetic complications, hypertriglyceridemia, hyperinsulinemia, atherosclerosis, impaired glucose homeostasis, impaired glucose tolerance, infertility, polycystic ovary syndrome, growth disorders, frailty, arthritis, allograft rejection in transplantation, autoimmune diseases, AIDS, intestinal diseases, inflammatory bowel syndrome, nervosa, osteoporosis, or an immunomodulatory disease or a chronic inflammatory bowel disease, which comprises administering to a mammalian species in need of treatment or an effective amount of a crystalline compound of the structure

• in the form of a hydrate thereof, a solvate thereof, or the free base thereof or a pharmaceutically acceptable salt thereof other than a trifluoroacetic acid salt, alone or in combination with another therapeutic agent.

23-25. (canceled)

The method according to claim 41, wherein the crystalline compound of form H-1 (1PhCO2H/1H2O) according to claim 57 has an observed powder x-ray diffraction pattern as shown in FIG. 22.