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US 2011/0257032 A1Published application
Modular glycan arrays
AssigneeMassachusetts Institute of Technology
InventorsRam Sasisekharan, Karthik Viswanathan, Udayanath Aich, Rahul Raman, Zachary Shriver, Ido Bachelet
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Abstract
The present invention provides methods and systems for functionally analyzing glycans and their interaction partners. Among other things, the invention provides modular glycan arrays in which different glycan populations are associated with different discrete solid phase particles. Provided arrays offer many advantages over available systems for assessing glycan binding interactions.
Claims25
A particulate array comprising:
- a first plurality of solid phase particles, each of which is associated with a first glycan population;
- a second plurality of solid phase particles, each of which is associated with a second glycan population, different from the first glycan population.
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A method comprising steps of:
- contacting a sample that contains a glycan binding agent with a particulate array comprising a first plurality of solid phase particles, each of which is associated with a first glycan population;
- a second plurality of solid phase particles, each of which is associated with a second glycan population, different from the first glycan population;
- and
- detecting binding to at least one of the pluralities of solid phase particles in the array.
1 more element
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Dependencies are inferred from the claim text.