Loading patent…
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsLynn Macdonald, Richard Torres, Marc R. Morra, Joel H. Martin, Joel C. Reinhardt
Estimating the term…
A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affinity of about 2-10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from burns, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.
An isolated nucleic acid molecule encoding a human antibody or antigen-binding fragment thereof that specifically binds human nerve growth factor (NGF), wherein the antibody or antigen-binding fragment thereof comprises the three heavy chain CDRs (HCDR1, HCDR2 and HCDR3) contained within any one of the HCVR amino acid sequences selected from the group consisting of SEQ ID NOs:
An isolated nucleic acid molecule encoding a human antibody or antigen-binding fragment thereof that specifically binds human nerve growth factor (NGF), wherein the antibody or antigen-binding fragment thereof comprises a heavy chain variable region (HCVR) selected from the group consisting of SEQ ID NOs:100 and 108.
An isolated nucleic acid molecule encoding a human antibody or antigen-binding fragment thereof that specifically binds human nerve growth factor (NGF), wherein the antibody or antigen-binding fragment thereof comprises a light chain variable region (LCVR) selected from the group consisting of SEQ ID NOs:
Dependencies are inferred from the claim text.