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AssigneeEisai R&D Management Co., Ltd.
InventorsYuichi Ono, Tomoya Nakatani, Yasuko Nakagawa
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The present invention provides markers that can selectively distinguish pancreatic progenitor cells. The present invention also provides methods for distinguishing pancreatic progenitor cells by using the markers as an indicator, and reagents to be used in the methods. The present inventors successfully identified the surface marker Nephrin-like 3 (Neph3) which is specifically expressed in pancreatic progenitor cells, and isolated pancreatic progenitor cells using the marker as an indicator or such. Viable pancreatic progenitor cells can be selected by using Neph3 as an indicator without using translated products and transcripts of any foreign genes. The marker is useful in preparing and identifying pancreatic progenitor cells which are applied to regenerative medicine or such for treatment of pancreatic diseases.
A method for producing a cell population comprising a pancreatic progenitor cell, which comprises the step of distinguishing, detecting, and/or identifying the expression of a translated product of a Nephrin-like 3 (Neph3) gene in an endodermal cell sample, and the step of collecting, isolating, and/or obtaining a cell expressing the translated product of the gene.
A method for distinguishing, detecting, identifying, collecting, isolating, and/or obtaining a pancreatic progenitor cell, which comprises the step of distinguishing, detecting, and/or identifying the expression of a translated product of a Neph3 gene in an endodermal cell sample.
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