mRNA expression-based prognostic gene signature for non-small cell lung cancer
OwnerNancy Lan Guo, Ying-Wooi Waninventors
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Abstract
A non-small cell lung cancer postoperative survival prognosticator comprising a detection mechanism consisting of 15-gene, 12-gene, and 16-gene signature and methods of use. Also provided are the identification of various subsets from the 25 prognostic signature genes with potential of operative survival prognosticator for non-small cell lung cancer patients in all tumor stage and early stage and potential for chemoresponse with a method of use.
Claims18
A method comprising creating a sample by extracting target polynucleotide molecules from an individual afflected with non-small cell lung cancer so that the RNA is preserved, deriving the mRNA from the mRNA of the individual, labeling the mRNA and hybridizing to a detection mechanism containing 12 or more of Seq ID No. 1, Seq. ID No. 2, Seq ID No. 3, Seq ID No. 4, Seq ID No. 5, Seq ID No. 6, Seq ID No. 7, Seq ID No. 8, Seq ID No. 9, Seq ID No. 10, Seq ID No. 11, Seq ID No. 12, Seq ID No. 13, Seq ID No. 14, Seq ID No. 15, Seq ID No. 16, Seq ID No. 17, Seq ID No. 18, Seq ID No. 19, Seq ID No. 20, Seq ID No. 21, Seq ID No. 22, Seq ID No. 23, Seq ID No. 24, Seq ID No. 25 wherein the individual is classified based upon a quantitative expression profile compared to a control.
A method comprising creating a sample by extracting target polynucleotide molecules from an individual afflected with non-small cell lung cancer so that the RNA is preserved, deriving the nucleic acids from the mRNA of the individual, labeling the nucleic acids and hybridizing to a detection mechanism containing 12 or more of Seq ID No. 1, Seq. ID No. 2, Seq ID No. 3, Seq ID No. 4, Seq ID No. 5, Seq ID No. 6, Seq ID No. 7, Seq ID No. 8, Seq ID No. 9, Seq ID No. 10, Seq ID No. 11, Seq ID No. 12, Seq ID No. 13, Seq ID No. 14, Seq ID No. 15, Seq ID No. 16, Seq ID No. 17, Seq ID No. 18, Seq ID No. 19, Seq ID No. 20, Seq ID No. 21, Seq ID No. 22, Seq ID No. 23, Seq ID No. 24, Seq ID No. 25 wherein the individual is classified based upon a quantitative expression profile compared to a control.
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