Arginine-containing compositions and methods for treating red blood cells
AssigneeViacell, Inc.
InventorsDaniel G. Ericson, Jeffrey A. Thompson
Life of this patent
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Abstract
Blood storage and/or rejuvenating compositions that include D-ribose and an arginine (e.g. L-arginine, D-arginine, or a combination thereof) are disclosed herein. Such compositions can be useful in methods for treating (e.g., storing and/or rejuvenating) red blood cells.
Claims54
A blood storage and/or rejuvenating composition comprising D-ribose and L-arginine and/or D-arginine.
A blood storage and/or rejuvenating composition comprising:
- 75 to 1500 mM L-arginine;
- and
- 75 to 1500 mM inosine,
- wherein the composition is an aqueous solution.
A blood storage and/or rejuvenating composition comprising:
- 300 mM L-arginine;
- 300 mM inosine;
- 300 mM D-ribose;
- 300 mM sodium pyruvate;
- and
- 300 mM inorganic phosphate,
- wherein the composition is an aqueous solution.
A method of rejuvenating blood, the method comprising:
- providing red blood cells having a 2,3-diphosphoglycerate value lower than the value for freshly drawn blood;
- mixing the red blood cells with a blood storage and/or rejuvenating composition under conditions effective to increase the 2,3-diphosphoglycerate value,
- wherein the blood storage and/or rejuvenating composition comprises L-arginine and/or D-arginine.
A method of rejuvenating blood, the method comprising:
- providing red blood cells having an adenosine triphosphate value lower than the value for freshly drawn blood;
- mixing the red blood cells with a blood storage and/or rejuvenating composition under conditions effective to increase the adenosine triphosphate value,
- wherein the blood storage and/or rejuvenating composition comprises L-arginine and/or D-arginine.
A method of rejuvenating blood, the method comprising:
- providing red blood cells having a reduced glutathione value lower than the value for freshly drawn blood;
- mixing the red blood cells with a blood storage and/or rejuvenating composition under conditions effective to increase the reduced glutathione value,
- wherein the blood storage and/or rejuvenating composition comprises L-arginine and/or D-arginine.
A method of rejuvenating blood, the method comprising:
- providing red blood cells having an oxygen dissociation P50 value lower than the value for freshly drawn blood;
- mixing the red blood cells with a blood storage and/or rejuvenating composition under conditions effective to increase the oxygen dissociation P50 value,
- wherein the blood storage and/or rejuvenating composition comprises L-arginine and/or D-arginine.
Dependencies are inferred from the claim text.