Use of Quaternary Ammonium Compounds to Inhibit Endogenous MMPs in Tooth Dentin
OwnerDavid Henry Pashley, Franklin Chin-Meng Tay +1inventors
InventorsDavid Henry Pashley, Franklin Chin-Meng Tay, Milena Cadenaro
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Abstract
Disclosed are compositions and methods of using such compositions for inhibiting matrix metalloproteinase activity in dental tissue. The compositions, methods and uses may prevent degradation of the bonding between restorative materials and dental tissues, thereby increasing durability and longevity of the restorative material-dental tissue bonds. For example, the compositions, methods, and uses of the present invention may be used for treating carious dental tissue such as by the creation of dental fillings, crowns, bridges, among other techniques, as well as the creation of esthetic laminate restorations.
Claims22
A composition comprising polymerizable quaternary ammonium monomers capable of inhibiting matrix metalloproteinase activity in dental tissue.
A method of inhibiting matrix metalloproteinase activity in dental tissue in a subject comprising administering to the subject a dental composition comprising polymerizable quaternary ammonium monomers of Formula I
- wherein X is selected from the group consisting of —R4—O—C(O)C(R5)═CH2, —CH2—CH═CH2, and
- wherein Y is selected from the group consisting of hydrogen, methyl, and —CH2—CH═CH2;
- or X and Y together with the nitrogen atom to which they are attached form a five membered ring with X and Y having the structure —CH2—C(R6)H—C(R7)H—CH2—;
- wherein Z is a counterion sufficient to balance the charge of the monomer;
- wherein R1 is selected from the group consisting of hydrogen and C1-2alkyl;
- wherein R2 is selected from the group consisting of hydrogen and C1-2alkyl;
- wherein R4 is C2-3alkylene;
- wherein R5 is selected from the group consisting of hydrogen and methyl;
- wherein R6 is an ethylene, acrylate or methacrylate group;
- and
- wherein R7 is an ethylene, acrylate or methacrylate group.
A method of repairing dental caries in a tooth comprising the steps:
- a) drilling the tooth;
- b) acid-etching the tooth;
- c) administering a dental adhesive wherein the dental adhesive comprises a compound of Formula I
- wherein X is selected from the group consisting of —R4—O—C(O)C(R5)═CH2, —CH2—CH═CH2, and
- wherein Y is selected from the group consisting of hydrogen, methyl, and —CH2—CH═CH2;
- or X and Y together with the nitrogen atom to which they are attached form a five membered ring with X and Y having the structure —CH2—C(R6)H—C(R7)H—CH2—;
- wherein Z is a counterion sufficient to balance the charge of the monomer;
- wherein R1 is selected from the group consisting of hydrogen and C1-2alkyl;
- wherein R2 is selected from the group consisting of hydrogen and C1-2alkyl;
- wherein R4 is C2-3alkylene;
- wherein R5 is selected from the group consisting of hydrogen and methyl;
- wherein R6 is an ethylene, acrylate or methacrylate group;
- and
- wherein R7 is an ethylene, acrylate or methacrylate group.
A use of a compound of Formula I for preparation of a medicament for treatment of tooth decay
- wherein X is selected from the group consisting of —R4—O—C(O)C(R5)═CH2, —CH2—CH═CH2, and
- wherein Y is selected from the group consisting of hydrogen, methyl, and —CH2—CH═CH2;
- or X and Y together with the nitrogen atom to which they are attached form a five membered ring with X and Y having the structure —CH2—C(R6)H—C(R7)H—CH2—;
- wherein Z is a counterion sufficient to balance the charge of the monomer;
- wherein R1 is selected from the group consisting of hydrogen and C1-2alkyl;
- wherein R2 is selected from the group consisting of hydrogen and C1-2alkyl;
- wherein R4 is C2-3alkylene;
- wherein R5 is selected from the group consisting of hydrogen and methyl;
- wherein R6 is an ethylene, acrylate or methacrylate group;
- and
- wherein R7 is an ethylene, acrylate or methacrylate group.
A use of a compound of Formula I for treatment of tooth decay
- wherein X is selected from the group consisting of —R4—O—C(O)C(R5)═CH2, —CH2—CH═CH2, and
- wherein Y is selected from the group consisting of hydrogen, methyl, and —CH2—CH═CH2;
- or X and Y together with the nitrogen atom to which they are attached form a five membered ring with X and Y having the structure —CH2—C(R6)H—C(R7)H—CH2—;
- wherein Z is a counterion sufficient to balance the charge of the monomer;
- wherein R1 is selected from the group consisting of hydrogen and C1-2alkyl;
- wherein R2 is selected from the group consisting of hydrogen and C1-2alkyl;
- wherein R4 is C2-3alkylene;
- wherein R5 is selected from the group consisting of hydrogen and methyl;
- wherein R6 is an ethylene, acrylate or methacrylate group;
- and
- wherein R7 is an ethylene, acrylate or methacrylate group;
- wherein the compound of Formula I is incorporated into a dental adhesive.
Dependencies are inferred from the claim text.