Methods and compositions for the treatment of cancer
AssigneeTraslational Cancer Drugs Pharma, S.L.
InventorsAna Ramirez De Molina, Lourdes Garcia Oroz, Juan Carlos Lacal Sanjuan
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Abstract
The invention relates to compositions comprising an acid ceramidase inhibitor and a choline kinase inhibitor as well as to the uses thereof for the treatment of cancer. The invention also relates to methods for the selection of an individualised therapy of a cancer patient based on the detection of the acid ceramidase levels. Moreover, the invention also relates to compositions comprising a choline kinase inhibitor and a chemotherapeutic agent and uses thereof for the treatment of cancer. Finally, the invention also relates to compositions comprising a choline kinase inhibitor and a death receptor ligand and uses thereof for the treatment of cancer.
Claims23
1-22. (canceled)
A composition comprising, separately or together, a first component comprising one or more choline kinase inhibitors and a second component selected from the group of one or more acid ceramidase inhibitors, one or more chemotherapy agents and one or more ligands for a death receptor.
A method for the treatment of cancer in a subject in need thereof comprising the administration to said subject a composition comprising, separately or together, a first component comprising one or more choline kinase inhibitors and a second component selected from the group of one or more acid ceramidase inhibitors, one or more chemotherapy agents and one or more ligands for a death receptor.
Dependencies are inferred from the claim text.