Controlled release compositions comprising meclizine or related piperazine derivatives
AssigneeEurand, Inc.
InventorsGopi M. VENKATESH, Troy M. HARMON
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Abstract
The present invention provides pharmaceutically acceptable compositions for once-daily dosing comprising a piperazine derivative of H1-receptor antagonists, or its salt, and/or solvate and methods of making and using the compositions in the treatment of treating vertigo and other diseases. The present invention also provides once-a-day dosage forms as orally disintegrating tablets comprising compositions of the present invention.
Claims39
A pharmaceutical multiparticulate composition comprising a plurality of drug particles comprising a weakly basic, piperazine derivative of H1-receptor antagonists, each particle comprising:
- a) an organic acid core comprising a pharmaceutically acceptable organic acid;
- b) a first coating disposed over the organic acid cores comprising at least one water-insoluble polymer, thereby forming a controlled release coated acid core;
- c) a second coating disposed over said controlled release coated acid core comprising a weakly basic piperazine derivative of H1-receptor antagonists and a polymeric binder;
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- d) a third coating disposed over the drug core comprising at least one water-insoluble polymer, thereby forming a controlled release coated drug particle.
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A pharmaceutical multiparticulate composition comprising a plurality of drug particles comprising a weakly basic piperazine derivative of H1-receptor antagonists, each particle comprising:
- a) a core comprising a solid dispersion of said weakly basic piperazine derivative of H1-receptor antagonists in a pharmaceutically acceptable solubility-enhancing water soluble polymer;
- b) a first coating disposed over said solid dispersion core comprising at least one water-insoluble polymer, thereby forming a controlled release coated drug particle.
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Dependencies are inferred from the claim text.