Immunocompatible amniotic membrane products
OwnerSamson Tom, Alla Danilkovitch +4inventors
InventorsSamson Tom, Alla Danilkovitch, Dana Yoo, Timothy Jansen, Jin-Qiang Kuang, Jennifer Michelle Marconi
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Abstract
Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
Claims133
A placental product comprising:
- a amniotic membrane, wherein the amniotic membrane:
- a. comprises viable therapeutic cells;
- and
- b. is substantially free of functional CD14+ macrophages;
- and
- optionally, wherein the viable therapeutic cells are native to the amniotic membrane.
A placental product comprising:
- a cryopreservation medium and an amniotic membrane, wherein:
- a. the amniotic membrane is substantially free of functional CD14+ macrophages;
- and
- b. the cryopreservation medium comprises a cryopreserving amount of a cryopreservative;
- and
- optionally, wherein the amniotic membrane is substantially free of vascularized tissue or vascularized tissue-derived immunogenic cells.
A placental product comprising:
- a cryopreservation medium and an amniotic membrane, wherein:
- a. the amniotic membrane:
- i. comprises a compact layer, layer of fibroblast, and a spongy layer, wherein each of said layers comprises viable therapeutic cells;
- and
- ii. is substantially free of vascularaized tissue and functional CD14+ macrophages;
- and
- b. the cryopreservation medium comprises a cryopreserving amount of a cryopreservative.
A method of treating a wound of a subject comprising administering the placental product of any of the preceding Claims to the wound.
Dependencies are inferred from the claim text.