Genes encoding major capsid protein l1 of human papilloma virus

An expression vector, wherein said expression vector comprises the sequence of a gene encoding the major capsid protein L1 of human papilloma virus, wherein said gene has codons preferred by Pichia yeast;

• and either:
• has an amino acid sequence set forth in SEQ ID NO 10 or in positions 62 to 568 of SEQ ID NO 10 and has a nucleotide sequence selected from SEQ ID NO 1, SEQ ID NO 2, SEQ ID NO 3, SEQ ID NO 4, SEQ ID NO 5, AND SEQ ID NO 6;
• or
• has an amino acid sequence set forth in SEQ ID NO 11 and has a nucleotide sequence selected from SEQ ID NO 7, SEQ ID NO 8, and SEQ ID NO 9.

A genetically engineered host cell, wherein said cell has a gene integrated into its genome, wherein said gene (1) encodes the major capsid protein L1 of human papilloma virus, (2) has codons preferred by Pichia yeast;

• and (3) either:
• (a) has an amino acid sequence set forth in SEQ ID NO 10 or in positions 62 to 568 of SEQ ID NO 10 and has a nucleotide sequence selected from SEQ ID NO 1, SEQ ID NO 2, SEQ ID NO 3, SEQ ID NO 4, SEQ ID NO 5, AND SEQ ID NO 6;
• or
• (b) has an amino acid sequence set forth in SEQ ID NO 11 and has a nucleotide sequence selected from SEQ ID NO 7, SEQ ID NO 8, and SEQ ID NO 9.