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OwnerJon B. KORSHUS, Paul L. Runnels +3inventors
InventorsJon B. KORSHUS, Paul L. Runnels, Richard L. Sharpee, Ronald F. Schell, Steven M. Callister
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A bacterin including effective immunizing amounts of two non-crossprotective isolates of inactivated Borrelia burgdorferi, an adjuvant in an amount effective to enhance the immunogenicity of the inactivated Borrelia burgdorferi isolates and a suitable carrier is provided herein. The bacterin may also contain a third non-crossprotective isolate. A bacterin including effective immunizing amounts of an antigenic subunit derived from a first Borrelia burgdorferi isolate and a second, non-crossprotective Borrelia burgdorferi isolate, an adjuvant in an amount effective to enhance the immunogenicity of the antigenic subunits and a suitable carrier is also provided. The bacterin may also contain an effective immunizing amount of an antigenic subunit of a third Borrelia burgdorferi. Further provided is a bacterin which includes effective immunizing amounts of two non-crossprotective isolates of inactivated Borrelia burgdorferi and one or more antigenic subunits from the non-crossprotective isolates, an adjuvant in an amount effective to enhance the immunogenicity of the inactivated Borrelia burgdorferi and antigenic subunits and a suitable carrier.
A bacterin which comprises per dose an effective immunizing amount of two non-crossprotective inactivated Borrelia burgdorferi isolates, an adjuvant in an amount effective to enhance the immunogenicity of the inactivated Borrelia burgdorferi isolates and a suitable carrier.
A bacterin which comprises per dose an effective immunizing amount of an antigenic subunit derived from a first Borrelia burgdorferi isolate, an effective immunizing amount of an antigenic subunit derived from a second, non-crossprotective Borrelia burgdorferi isolate, an adjuvant in an amount effective to enhance the immunogenicity of the antigenic subunits and a suitable carrier.
A bacterin which comprises per dose an effective immunizing amount of two non-crossprotective isolates of inactivated Borrelia burgdorferi and one or more antigenic subunits from the non-crossprotective isolates, an adjuvant in an amount effective to enhance the immunogenicity of the inactivated Borrelia burgdorferi and antigenic subunits and a suitable carrier.
The use of a bacterin which comprises an effective immunizing amount of at least two non-crossprotective isolates of inactivated Borrelia burgdorferi, an adjuvant in an amount effective to enhance the immunogenicity of the inactivated Borrelia burgdorferi and a suitable carrier for the immunization of animals against infection by Borrelia burgdorferi.
The use of a bacterin which comprises an effective immunizing amount of at least two non-crossprotective isolates of inactivated Borrelia burgdorferi and one or more antigenic subunits from the non-crossprotective isolates, an adjuvant in an amount effective to enhance the immunogenicity of the inactivated Borrelia burgdorferi and antigenic subunits and a suitable carrier for the immunization of animals against infection by Borrelia burgdorferi.
Dependencies are inferred from the claim text.