Herpes simplex virus combined subunit vaccines and methods of use thereof
AssigneeThe Trustees of the University of Pennsylvania
InventorsHarvey FRIEDMAN, Sita AWASTHI, John LUBINSKI
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Abstract
This invention provides vaccines comprising two or more recombinant Herpes Simplex Virus (HSV) proteins selected from a gD protein, a gC protein and a gE protein; and methods of impeding immune evasion by HSV thereby vaccinating a subject against HSV and treating, suppressing, inhibiting, and/or reducing an incidence of an an HSV infection or a symptom or manifestation thereof, comprising administration of a vaccine of the present invention.
Claims31
A vaccine consisting of two or three recombinant Herpes Simplex Virus (HSV) proteins selected from:
- a. a recombinant HSV gD protein or immunogenic fragment thereof;
- b. a recombinant HSV gC protein or fragment thereof, wherein said fragment comprises either a C3b-binding domain thereof, a properdin interfering domain thereof, a C5 interfering domain thereof, or a fragment of said C3b-binding domain, properdin interfering domain, or C5-interfering domain;
- and
- c. a recombinant HSV gE protein or fragment thereof, wherein said fragment comprises AA 24-409 or a fragment thereof;
- and an adjuvant;
- wherein administration of said vaccine to a human subject elicits anti-HSV HSV antibodies, wherein said antibodies blocks an immune evasion function of an HSV protein.
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Dependencies are inferred from the claim text.