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US 2011/0256173 A1Published application
Chemical synthesis of phosphatidylinositol mannoside glycans from mycobacterium tuberculosis
AssigneeMax-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
InventorsPeter H. Seeberger, Siwarutt Boonyarattanakalin, Bernd Lepenies
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Abstract
The efficient synthesis of phosphatidylinositol mono- to hexa-mannoside (PIM1 to PIM6) is reported. The invention relates to these phosphatidylinositol mono- to hexa-mannosides carrying a linker and a reactive functional group, e.g. the sulfhydryl group, a protein, a fluorescent probe, or a solid phase. The invention further relates to vaccines comprising the PIMs linked to a carrier protein or an antigen
Claims13
A compound of formula (I)
- wherein
- RA is H, a residue of formula (II), (III), (IV), (V) or (VI)
- and RB is —(CH2)n—X wherein n is from 2 to 10 or —(CH2CH2O)mCH2CH2X wherein m is from 1 to 5, and X is a reactive functional group, a protein, a fluorescent probe or a solid phase.
Dependencies are inferred from the claim text.