Plasmids coding for p185neu protein sequence variants and therapeutic uses thereof

A method of treating or preventing p185′-positive tumors, metastases or tumor relapses, said method comprising administering to a subject in need thereof a plasmid vector for DNA transfer, which plasmid contains a sequence selected from SEQ ID NO:

• 6, 7, 8, 9, 10, 11, 12 coding for a chimeric p185′-protein, or a pharmaceutical composition containing said plasmid vector together with pharmaceutically acceptable vehicles and excipients.