Methods Of Treating And Preventing Glucose Toxicity
OwnerAndreas Strasser, Mark McKenzie +3inventors
InventorsAndreas Strasser, Mark McKenzie, Helen Thomas, Janette Allison, Tom Kay
Life of this patent
Estimating the term…
Abstract
The present invention relates to a method for treating and/or preventing a disease associated with glucose toxicity in a subject which may comprise administering to the subject a compound that reduces the level of Bim, PUMA and/or Bax activity in a cell of the subject. Furthermore, provided is a method for culturing cells susceptible to exposure to high concentrations of glucose, which may comprise delivering to the cells, or progenitor cells thereof, a compound that reduces the level of Bim, PUMA and/or Bax activity in the cells.
Claims21
1-14. (canceled)
A method for treating and/or preventing a disease associated with glucose toxicity in a subject, the method comprising administering to the subject a compound that reduces the level of Bim, PUMA and/or Bax activity in a cell of the subject.
A method for treating and/or preventing a disease associated with glucose toxicity in a subject, the method comprising
- i) administering cells in vitro with a compound that reduces the level of Bim, PUMA and/or Bax activity in a cell, and
- ii) administering the cells from step i) into the subject.
A method for culturing cells susceptible to exposure to high concentrations of glucose, the method comprising delivering to the cells, or progenitor cells thereof, a compound that reduces the level of Bim, PUMA and/or Bax activity in the cells.
A cell comprising an exogenous compound that reduces the level of Bim, PUMA and/or Bax activity, wherein an isogenic cell lacking said exogenous compound is susceptible to glucose toxicity.
A method of identifying a compound for treating and/or preventing a disease associated with glucose toxicity, the method comprising
- i) identifying a compound which binds Bim, PUMA and/or Bax,
- ii) determining if the compound reduces the level of Bim, PUMA and/or Bax activity in a cell.
A method of identifying a compound for treating and/or preventing a disease associated with glucose toxicity, the method comprising
- i) identifying a compound which hybridizes to a gene encoding Bim, PUMA and/or Bax, or a transcription product thereof, and
- ii) determining if the compound reduces the production of Bim, PUMA and/or Bax in a cell,
- wherein the compound is a polynucleotide.
A method of identifying a compound for treating and/or preventing a disease associated with glucose toxicity, the method comprising
- i) identifying a compound comprising an oligonucleotide which comprises at least 19 contiguous nucleotides of any one or more of the sequence of nucleotides provided as SEQ ID NOs 14 to 26, wherein the compound comprises a double-stranded portion that is at least 19 basepairs in length which comprises said oligonucleotide, and
- ii) determining if the compound reduces the production of Bim, PUMA and/or Bax in a cell,
- wherein the compound is a polynucleotide.
Dependencies are inferred from the claim text.