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US 2011/0256146 A1Published application
Neuropilin antagonists
AssigneeGenentech, Inc.
InventorsRyan J. Watts, Yan Wu
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Abstract
Novel anti-NRP1 antibodies and variants thereof having unique structural and functional characteristics are disclosed. Also provided are uses of the antibodies in research, diagnostic and therapeutic applications.
Claims17
Use of an anti-neuropilin-1 (NRP1) antibody capable of inhibiting at least one neuropilin (NRP) mediated biological activity, which comprises a light chain variable domain comprising the following CDR amino acid sequences:
- CDRL1 (RASQYFSSYLA;
- SEQ ID NO:
- 129), CDRL2 (GASSRAS;
- SEQ ID NO:
- 130) and CDRL3 (QQYLGSPPT;
- SEQ ID NO:
- 131) in the manufacture of a medicament for the treatment or prevention of a disorder associated with pathological angiogenesis in a mammal.
4 more elements
Dependencies are inferred from the claim text.