Connective Tissue Growth Factor-3 (CTGF-3)
AssigneeHuman Genome Sciences, Inc.
InventorsReinhard Ebner, Arvind Chopra, Steven M. Ruben
Life of this patent
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Abstract
The present invention relates to a novel connective tissue growth factor-3 protein which is a member of the growth factor superfamily. In particular, isolated nucleic acid molecules are provided encoding the human connective tissue growth factor-3 protein. Connective tissue growth factor-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods for detecting and treating connective tissue related disorders.
Claims20
An isolated nucleic acid molecule comprising a polynucleotide having a nucleotide sequence at least 95% identical to a sequence selected from the group consisting of:
- (a) a nucleotide sequence encoding a polypeptide comprising amino acids from about −19 to about 231 in SEQ ID NO:2;
- (b) a nucleotide sequence encoding a polypeptide comprising amino acids from about −18 to about 231 in SEQ ID NO:2;
- (c) a nucleotide sequence encoding a polypeptide comprising amino acids from about 1 to about 231 in SEQ ID NO:2;
- (d) a nucleotide sequence encoding a polypeptide having the amino acid sequence encoded by the cDNA clone contained in ATCC™ Deposit No. 97756;
- (e) a nucleotide sequence encoding the mature connective tissue growth factor-3 polypeptide having the amino acid sequence encoded by the cDNA clone contained in ATCC™ Deposit No. 97756;
- and
- (f) a nucleotide sequence complementary to any of the nucleotide sequences in (a), (b), (c), (d), or (e).
An isolated connective tissue growth factor-3 polypeptide having an amino acid sequence at least 95% identical to a sequence selected from the group consisting of:
- (a) amino acids from about −19 to about 231 in SEQ ID NO:2;
- (b) amino acids from about −18 to about 231 in SEQ ID NO:2;
- (c) amino acids from about 1 to about 231 in SEQ ID NO:2;
- (d) the amino acid sequence of the connective tissue growth factor-3 polypeptide having the amino acid sequence encoded by the cDNA clone contained in ATCC™ Deposit No. 97756;
- (e) the amino acid sequence of the mature connective tissue growth factor-3 polypeptide having the amino acid sequence encoded by the cDNA clone contained in ATCC™ Deposit No. 97756;
- and
- (f) the amino acid sequence of an epitope-bearing portion of any one of the polypeptides of (a), (b), (c), (d), or (e).
A diagnostic method, comprising:
- (a) assaying connective tissue growth factor-3 gene expression level in mammalian cells or body fluid;
- and
- (b) comparing said connective tissue growth factor-3 gene expression level with a standard connective tissue growth factor-3 gene expression level, whereby an increase or decrease in said connective tissue growth factor-3 gene expression level compared to said standard is indicative of a connective tissue-related disorder.
Dependencies are inferred from the claim text.