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AssigneeMicromet AG
InventorsPeter Kufer, Meera Berry, Sonja Offner, Klaus Brischwein, Andreas Wolf, Tobias Raum, Birgit Kohleisen, Ulla Lenkkeri-Schutz, Patrick Bauerle
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The present invention provides a pharmaceutical composition comprising a bispecific single chain antibody construct. Said bispecific single chain antibody construct is characterized to comprise or consist of at least two domains, whereby one of said at least two domains specifically binds to human EpCAM and comprises at least one CDR-H3 region comprising the amino acid sequence NXID antigen and a second domain binds to human CD3 antigen. The invention further provides a process for the production of the pharmaceutical composition of the invention, a method for the prevention, treatment or amelioration of a tumorous disease and the use of the disclosed bispecific single chain antibody construct and corresponding means in the prevention, treatment or amelioration of a tumorous disease.
A bispecific single chain antibody construct, whereby said construct comprises at least two domains, whereby one of said domains binds to human EpCAM antigen and a second domain binds to human CD3 antigen, wherein said binding domain specific for EpCAM comprises at least one CDR-H3 region comprising the amino acid sequence NXD preferably in position 102 to 104 of SEQ ID NOs:
A pharmaceutical composition comprising a bispecific single chain antibody construct, whereby said construct comprises at least two domains, whereby one of said at least two domains specifically binds to human EpCAM antigen and a second domain binds to human CD3 antigen, wherein said binding domain specific for EpCAM comprises at least one CDR-H3 region of at least 9 amino acid residues and wherein said binding domain specific for EpCAM has a KD value of more than 5×10−9 M.
A pharmaceutical composition of claim 26, further comprising a proteinaceous compound capable of providing an activation signal for immune effector cells.
(canceled)
A method for the prevention, treatment or amelioration of a tumorous disease, comprising the step of administering to a subject in need of such a prevention, treatment or amelioration a pharmaceutical composition of claim 26.
Dependencies are inferred from the claim text.