Complement Inhibitors For Treatment Of Injury From Intracerebral Hemorrhage
AssigneesThe Trustees of the University of Pennsylvania, The Trustees of Columbia University
InventorsJohn D. Lambris, E. Sander Connolly, JR.
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Abstract
Methods for treating or ameliorating the damage resulting from intracerebral hemorrhage are disclosed. The methods involve administration of a complement inhibitor to inhibit C3a or C5a formation or activity in the affected tissue. Pharmaceutical compositions suitable for use in the methods of the invention are also provided.
Claims24
A method for treating or preventing injury resulting from intracerebral hemorrhage in an individual, the method comprising administering a therapeutically effective amount of a complement inhibitor to the individual, wherein the complement inhibitor reduces or prevents C3a or C5a formation or activity, thereby treating or preventing the injury resulting from intracerebral hemorrhage.
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A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an amount of a complement inhibitor effective to treat or prevent injury resulting from intracerebral hemorrhage.
Dependencies are inferred from the claim text.