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US 2011/0256135 A1Published application
Anti-nerve growth factor (ngf) antibody compositions
OwnerWolfgang FRAUNHOFER, Ravi Chari +5inventors
InventorsWolfgang FRAUNHOFER, Ravi Chari, Vineet Kumar, Rainer Saedler, Michael Siedler, William B. Stine, Carsten Weber
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Abstract
The present invention relates to stable compositions of anti-NGF antibodies, and antigen-binding fragments thereof, and their uses in the prevention and/or treatment of various diseases and disorders in which NGF activity is detrimental, e.g., pain disorders.
Claims48
A pharmaceutical composition comprising:
- (a) an anti-nerve growth factor (NGF) antibody, or antigen binding fragment thereof;
- (b) a histidine buffer at a concentration of about 5 to about 60 mM;
- and
- (c) polysorbate 80 at a concentration of about 0.01% to about 0.1%;
- wherein the pH of the composition is about 5.0 to about 6.0.
2 more elements
A pharmaceutical composition comprising:
- (a) an anti-nerve growth factor (NGF) antibody comprising a human IgG4 constant region, wherein the antibody comprises a heavy chain having the amino acid sequence of SEQ ID NO:13 and a light chain having the amino acid sequence of SEQ ID NO:16, wherein the concentration of the antibody, or antigen binding fragment thereof, is about 10 to about 50 mg/mL;
- (b) a histidine buffer at a concentration of about 10 to about 30 mM histidine;
- and
- (c) polysorbate 80 at a concentration of about 0.01% to 0.02%;
- wherein the pH of the composition is about 5.0 to about 6.0.
2 more elements
Dependencies are inferred from the claim text.