Anti-polyubiquitin antibodies and methods of use
AssigneeGenentech, Inc.
InventorsVISHVA DIXIT, ROBERT F. KELLEY, MARISSA L. MATSUMOTO
Life of this patent
Estimating the term…
Abstract
The invention provides anti-polyubiquitin antibodies and methods of using the same.
Claims43
An isolated antibody that specifically binds a first polyubiquitin comprising a K11 lysine linkage, wherein the antibody does not specifically bind a second polyubiquitin comprising a second lysine linkage, wherein the second lysine linkage differs from a K11 lysine linkage.
An isolated antibody that specifically binds both a first polyubiquitin comprising a K11 lysine linkage and a second polyubiquitin comprising a second lysine linkage, wherein the second lysine linkage differs from the K11 lysine linkage, wherein the antibody does not specifically bind monoubiquitin, and wherein the antibody binds the second polyubiquitin with a substantially reduced binding affinity as compared to the binding affinity of the antibody for the first polyubiquitin.
An isolated antibody that specifically binds lysine-11-linked polyubiquitin, wherein the antibody does not specifically bind monoubiquitin.
(canceled)
40-42. (canceled)
Dependencies are inferred from the claim text.