Anti-lrp6 antibodies
AssigneeGenentech, Inc.
InventorsEric Bourhis, Tim Cao, Rick Carano, Andrea Cochran, Mike Costa, Venita DeAlmeida, James Ernst, Yan Gong, Rami Hannoush, Paul Polakis, Bonnee Rubinfeld, Mark Solloway, Yan Wu
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Abstract
The invention provides anti-LRP6 antibodies and methods of using the same. A particular aspect of the invention provides for bispecific anti-LRP6 antibodies that inhibit signaling by multiple Wnt isoforms.
Claims31
An isolated antibody that binds to LRP6, wherein the antibody inhibits signaling induced by a first Wnt isoform and potentiates signaling induced by a second Wnt isoform.
A method of treating an individual having cancer comprising administering to the individual an effective amount of
- a) an isolated antibody that binds to LRP6 and inhibits signaling induced by a Wnt isoform selected from the group consisting of Wnt3 and Wnt3a, and
- b) an isolated antibody that binds to LRP6 and inhibits signaling induced by a Wnt isoform selected from the group consisting of Wnt 1, 2, 2b, 6, 8a, 9a, 9b, and 10b.
An isolated antibody that binds to LRP6, wherein the antibody comprises a VH comprising an amino acid sequence having at least 90% homology to an amino acid sequence selected from the group consisting of SEQ ID NO:
- 9, SEQ ID NO:
- 11, SEQ ID NO:
- 13, and SEQ ID NO:
- 15.
An isolated bispecific antibody that binds to two different regions of LRP6 wherein the antibody comprises a first VH comprising the amino acid sequence having at least 90% sequence identity to an amino acid sequence selected from the group consisting of SEQ ID NO:
- 9, SEQ ID NO:
- 11, and SEQ ID NO:
- 13 and a second VH comprising the amino acid sequence of SEQ ID NO:
- 15.
An isolated bispecific antibody that binds to two different regions of LRP6 wherein the antibody comprises a first VH domain comprising at least one, at least two, or all three VH HVR sequences selected from (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:
- 17 or SEQ ID NO:
- 20;
- (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:
- 18;
- and (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:
- 19 or SEQ ID NO:
- 21 and a second VH domain comprising at least one, at least two, or all three VH HVR sequences selected from (d) HVR-H1 comprising the amino acid sequence of SEQ ID NO:
- 22;
- (e) HVR-H2 comprising the amino acid sequence of SEQ ID NO:
- 23;
- and (f) HVR-H3 comprising the amino acid sequence of SEQ ID NO:
- 24.
An isolated bispecific antibody that binds to LRP6 and inhibits signaling induced by a Wnt isoform selected from the group consisting of Wnt3 and Wnt3a and inhibits signaling induced by a Wnt isoform selected from the group consisting of Wnt 1, 2, 2b, 6, 8a, 9a, 9b, and 10b.
Dependencies are inferred from the claim text.