Materials and methods for improved immunoglycoproteins
AssigneeTrubion Pharmaceuticals, Inc.
InventorsErik S. ESPLING, Peter A. THOMPSON, Peter R. BAUM
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Abstract
Immunoglycoproteins, including antibodies, with improved ADCC and altered glycosylation patterns are provided. Also provided are cell culturing methods and media for producing such immunoglycoproteins, and therapeutic uses of such immunoglycoproteins.
Claims11
A composition comprising recombinant immunoglycoprotein molecules, wherein the recombinant immunoglycoprotein molecules each comprise an N-linked glycosylation site for linkage of oligosaccharide, and wherein at least 60% of the N-linked oligosaccharides of the N-linked glycosylation site have a hexose content of at least ten hexose molecules.
Dependencies are inferred from the claim text.