Polypeptides, antibody variable domains & antagonists
OwnerIan Richard Catchpole, Fiona Cook +3inventors
InventorsIan Richard Catchpole, Fiona Cook, Gerald Gough, Laurent Jespers, Michael Steward
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Abstract
The present disclosure relates to immunoglobulin single variable domains (dAbs) e.g., dAbs which are protease resistant, and also to formulations, and compositions comprising such dAbs for ocular delivery and to their uses to treat ocular diseases and conditions.
Claims35
A composition comprising an immunoglobulin single variable domain that binds to a target molecule, for ocular delivery.
A composition comprising a naked immunoglobulin single variable domain which binds to a target molecule for delivery to one or more of the ocular regions selected from the group consisting of:
- the vitreous humour, the aqueous humour, the retina and the choroid.
A composition comprising a formatted immunoglobulin single variable domain which binds to a target molecule for delivery to one or more of the ocular regions selected, from the group consisting of:
- the retina, the choroid and the lachrymal fluid.
Dependencies are inferred from the claim text.