Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases
AssigneeThe Regents of the University of Michigan
InventorBruce Richardson
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Abstract
The present invention relates to compositions and methods for diagnosing, monitoring and/or treating disease (e.g., autoimmune or chronic inflammatory disease, heart disease and/or stroke). In particular, the present invention provides methods for diagnosing, monitoring and treating disease based upon detecting or altering (e.g., altering expression or methylation status of) disease proteins (e.g., CD70, CD40L, and/or KIR). The present invention also provides kits for detecting methylation status of disease proteins (e.g., CD70, CD40L, and/or KIR) and for diagnosing, monitoring and/or treating diseases (e.g., autoimmune or chronic inflammatory disease, heart disease and/or stroke).
Claims24
A method for detecting methylation status of KIR in a subject, comprising:
- a) providing a biological sample from said subject, wherein said biological sample comprises KIR nucleic acid sequence;
- b) exposing said sample to reagents for detecting methylation status of KIR nucleic acid sequence;
- c) detecting methylation status of KIR nucleic acid sequence in said sample;
- and
- d) comparing said methylation status of KIR nucleic acid sequence in said sample to the methylation status of KIR nucleic acid sequence in a control sample.
A method for treating a disease in a subject comprising providing a subject with a disease and administering a KIR-inhibiting agent to said subject.
A composition for treating a disease associated with autoreactive KIR+CD4+CD28− T cells comprising a KIR-inhibiting agent in a pharmaceutically appropriate formulation for administration to a human subject.
Dependencies are inferred from the claim text.