Manufacturing and use of composite scaffolds

A method of manufacturing a composite scaffold comprising:

• irradiating a three dimensional porous scaffold with gamma-rays;
• contacting the scaffold in a solution comprising an unsaturated carboxylic acid for introducing carboxyl groups at the surface of the scaffold;
• activating the carboxyl groups to obtain activated carboxyl groups;
• contacting the scaffold comprising the activated carboxyl groups with a first polymer solution in a first contacting step to allow reaction of the activated carboxyl groups with the polymer in the polymer solution;
• contacting the scaffold in a second contacting step with a second polymer solution;
• and
• irradiating the scaffold which is in contact with the second polymer solution with gamma-rays to obtain the composite scaffold.