Isolated multipotent mesenchymal stem cell from human adult glomeruli (hgl-msc), a method of preparing thereof and uses thereof in the regenerative medicine of the kidney
AssigneeFresenius Medical Care Deutschland GmbH
InventorsGiovanni Camussi, Stefenia Bruno, Benedetta Bussolati
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Abstract
The invention relates to an isolated multipotent glomerular mesenchymal stem cell derived from adult human kidney (hGL-MSC), which is characterised by the marker profile CD133−, CD146+, CD34− and CD105+. A method of preparing the hGL-MSC of the invention form decapsulated glomeruli is also disclosed, as well as the uses of the hGL-MSC of the invention in the regenerative treatment of the kidney, particularly for the treatment of injuries or diseases affecting renal glomeruli.
Claims21
1-20. (canceled)
An isolated multipotent glomerular mesenchymal stem cell derived from adult human kidney (hGL-MSC), characterised by the markers CD133(negative), CD146(positive), CD34(negative), CD105(positive), CD24(positive) and Pax-2(positive) and further characterised by the ability to differentiate into at least the following cell types:
- podocytes, endothelial cells and mesangial cells.
Dependencies are inferred from the claim text.