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US 2011/0256105 A1Published application
Cardiac stem cell and myocyte secreted paracrine factors
AssigneeThe Johns Hopkins University
InventorsEduardo Marban, Jennifer E. Van Eyk, Miroslava Stasna
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Abstract
The invention relates to secreted proteins from cardiac stem cells (cardiospheres and cardiosphere-derived cells) or myocytes for diagnostic and/or therapeutic use.
Claims18
A method for screening a cardiac patient as a candidate for stem cell therapy, said method comprising
- measuring in a biological sample from the patient the amount of expression of one or more of the proteins of Table 2, or a peptide fragment thereof, compared to a baseline value,
- wherein a statistically significant amount of over-expression of the protein(s) compared to the baseline value indicates that the patient would be likely to benefit from stem cell therapy.
A method of treating a cardiac patient comprising administering an effective amount of at least one protein or fragment thereof as set forth in Table 2 to said patient.
Dependencies are inferred from the claim text.