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AssigneeInstytut Immunologii I Terapii Doswiadczalnej Pan
InventorsEwa Zuziak, Andrzej Gamian, Andrzej Gorski, Tomasz Lipinski
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The subject the present invention is a method of producing a pharmacologically stable form of purified and lyophilised bacteriophage preparations of increased stability and antibacterial activity, characterised in that phages produced from a bacterial lysate, for example by ultrafiltration on ultrafiltration membranes, containing a high molecular weight preparation of purified phages is stabilised most preferably with a probiotic extract in the presence or absence of neutral salts and/or organic solvents, lyophilised, characterised via HPLC chromatography, by SDS-PAGE, and bacterial lysis biological assays, and then stored under a vacuum, where the active lyophilisate is destined for phage therapy of infections and tumours.
A method of producing pharmacologically stable forms of purified and lyophilised bacteriophage preparations with increased stability and antibacterial activity, characterised in that a high molecular weight phage preparation produced from a bacterial lysate is stabilised through the addition of a stabilising preparation, preferentially 2-4% probiotic, and in the presence or absence of neutral salts and/or organic solvents, the preparation is lyophilised under sterile conditions.
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