Secreted modular calcium binding protein for intracellular modulation of bone morphogenetic protein signaling
AssigneeKatholieke Universiteit Leuven
InventorsJohn Terrig Thomas, Malcolm C. Moos Jr., Frank Luyten
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Abstract
A method for modulating Bone Morphogenetic Protein (BMP) signaling activity in a cell or tissue of a vertebrate subject is provided which comprises administering a polynucleotide or polypeptide encoding a Secreted Modular Calcium Binding Protein (SMOC) polypeptide, or a conservatively modified variant, derivative, or analog thereof, in an amount effective to activate intracellular Mitogen Activated Protein (MAP) kinase activity and to reduce BMP signaling activity in the cell or tissue of the vertebrate subject. Methods for treating joint disorders in a mammalian subject are provided.
Claims30
A method for modulating growth and differentiation of bone and cartilage in a patient comprising administering to the patient an effective amount of a secreted modular calcium binding protein;
- a nucleic acid encoding a secreted modular calcium binding protein;
- a vector comprising a nucleic acid encoding a secreted modular calcium binding protein;
- or
- a host cell expressing a secreted modular calcium binding protein.
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A method for treating a musculoskeletal disorder comprising administering to a patient suffering from such a disorder a therapeutically effective amount of a secreted modular calcium binding protein;
- a nucleic acid encoding a secreted modular calcium binding protein;
- a vector comprising a nucleic acid encoding a secreted modular calcium binding protein;
- or
- a host cell expressing a secreted modular calcium binding protein.
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A method for modulating bone morphogenetic protein activity comprising activating an extracellular signal-regulated mitogen-activated protein kinase with a secreted modular calcium binding protein.
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Dependencies are inferred from the claim text.