A packaging material comprising a colored element which at a predetermined temperature below which the pharmaceutical product must be kept, discolors partially, revealing a marking, wherein:
- (a) the colored element comprises a first portion, which forms the marking printed with a conventional ink, and by a second portion printed with a thermochromic ink;
- (b) the thermochromic ink is colored below the predetermined temperature and becomes colorless when the predetermined temperature is reached or exceeded;
- and
- (c) the first portion and second portion are arranged so that the first portion is substantially invisible below said predetermined temperature, but becomes visible when the predetermined temperature is reached or exceeded,
- wherein the packaging material is suitable for a pharmaceutical product.