Metal coordination complexes of volatile drugs
AssigneeAlexza Pharmaceuticals, Inc.
InventorsRon L. HALE, C.V Krishnamohan Sharma, Mingzu Lei
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Abstract
The present disclosure provides a drug delivery device comprising a housing defining an airway, wherein the airway comprises at least one air inlet and a mouthpiece having at least one air outlet, at least one heated metal substrate disposed within the airway, at least one drug disposed on the at least one heated metal substrate. Drugs that can be complexed with metals or metal salts and could be deposited as thin films on heated metal substrate for generating thermal condensation aerosols are particularly suited. The metal substrate could be electrically or chemically heated. Further, the chemically heated metal source could be activated by an igniter that generates heat or spark.
Claims17
A thin film comprising a metal coordination complex, wherein the metal coordination complex comprises an organic compound that is selectively vaporizable from the metal coordination complex when the thin film is heated.
An aerosol drug delivery device comprising a heating package wherein a thin film comprising a metal coordination complex is disposed on said heating package, wherein the metal coordination complex comprises an organic compound that is selectively vaporizable from the metal coordination complex when the thin film is heated.
A method of producing an aerosol of a compound by selectively vaporizing the compound from a thin film comprising a metal coordination complex.
(canceled)
Dependencies are inferred from the claim text.