LCMV-GP-VSV-Pseudotyped Vectors and Tumor-Infiltrating Virus-Producing Cells for the Therapy of Tumors
AssigneeViratherapeutics GmbH
InventorsDorothee Von Laer, Tsanan Heimann
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Abstract
The invention relates to recombinant VSV viruses and viral vectors which produce a glycoprotein GP of the lymphocyte choriomeningitis virus (LCMV) instead of the G protein of the VSV, to virus producing cells which produce LCMV-GP-pseudotyped VSV virions, and to the use of said vectors and cells in the therapy of solid tumors, especially brain tumors.
Claims34
A VSV-LCMV-GP pseudotype vector, characterized in that the vector comprises a gene coding for a glycoprotein GP of the lymphocyte choriomeningitis virus (LCMV) and lacks a functional gene coding for envelope protein G of the VSV.
A VSV-LCMV-GP pseudotype vector system, characterized in that the system comprises at least two complementary replicating VSV vectors, wherein the system comprises genes n, l, p and m coding for proteins N, L, P and M of the VSV, a gene gp coding for LCMV-GP and lacks a functional gene coding for G protein of the VSV, wherein each vector of the system lacks one of the genes n, l, p, m and gp, and wherein the lacking gene is present on any other vector of the system.
A pseudotyped VSV virion, characterized in that the virion comprises a GP protein of the LCMV as envelope protein.
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Dependencies are inferred from the claim text.