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US 2011/0239316 A1Published application
ANTI-cMET ANTIBODY
AssigneePierre Fabre Medicament
InventorsLiliane Goetsch, Thierry Wurch, Cédric Bes
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Abstract
Antibody capable of binding specifically to the human c-Met receptor and/or capable of specifically inhibiting the tyrosine kinase activity of said receptor, with an improved antagonistic activity, said antibody comprising a modified hinge region. A composition comprising such an antibody antagonist to c-Met and its use as a medicament for treating cancer.
Claims46
A monoclonal antibody, or a divalent functional fragment or derivative thereof, capable of inhibiting c-Met dimerization, wherein the antibody comprises:
- a heavy chain comprising CDR-H1, CDR-H2, and CDR-H3 comprising amino acid sequences SEQ ID Nos. 1, 2, and 3, respectively;
- a light chain comprising CDR-L1, CDR-L2, and CDR-L3 comprising amino acid sequences SEQ ID Nos. 5, 6, and 7;
- and
- a modified hinge region comprising the amino acid sequence SEQ ID No. 56.
1 more element
Dependencies are inferred from the claim text.