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US 2011/0238382 A1Published application
Optimized method for lid biosensor resonance detection
AssigneeCorning Incorporated
InventorsJacques Gollier, Garrett A. Piech, Michael B. Webb, Qi Wu
Life of this patent
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Abstract
An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects.
Claims23
An optical interrogation system comprising:
- a launch system that emits an optical beam towards a biosensor;
- a receive system that collects an optical beam from the biosensor and then outputs a signal which corresponds to the collected optical beam;
- and
- the receive system includes a spectrometer which has a misaligned entrance spectrometer slit or fiber.
1 more element
An optical interrogation system comprising:
- a launch system that emits an optical beam towards a biosensor;
- a receive system that collects an optical beam from the biosensor and then outputs a signal which is representative of the collected optical beam;
- and
- a processor that reduces pixelation oscillations in an optical resonance of the signal by oversampling at least a portion of the optical resonance, smoothing the optical resonance and calculating a resonance location or centroid that is based on the smoothed-oversampled optical resonance.
1 more element
A method for interrogating a biosensor, said method comprising the steps of:
- emitting an optical beam towards a biosensor;
- collecting an optical beam from the biosensor
- generating a signal which corresponds to the collected optical;
- and
- reducing oscillations in an optical resonance of the signal caused by a problematical pixelation effect by:
- oversampling at least a portion of the optical resonance;
- smoothing the optical resonance;
- and
- calculating a resonance location or centroid that is based on the smoothed-oversampled optical resonance.
6 more elements
An optical interrogation system comprising:
- a launch system that emits an optical beam towards a biosensor;
- a receive system that collects an optical beam from the biosensor and then outputs a signal which corresponds to the collected optical beam;
- and
- a processor that applies a low pass filter to the signal, wherein the low pass filter has a low pass filter width wide enough to suppress detrimental effects of parasitic fringes located on each side of an optical resonance represented within the signal by applying the low pass filter to the signal, wherein the parasitic fringes are generated at least by presence of linearly polarized parasitic reflections, and wherein the linearly polarized parasitic reflections are caused by the optical beam which passes through a substrate of the biosensor and is then reflected from a top surface of the biosensor.
1 more element
A method for interrogating a biosensor, said method comprising the steps of:
- emitting an optical beam towards the biosensor;
- collecting an optical beam from the biosensor;
- generating a signal which corresponds to the collected optical beam;
- and
- applying a low pass filter to the signal, wherein the low pass filter has a low pass filter width wide enough to suppress detrimental effects of parasitic fringes located on each side of an optical resonance represented within the signal by applying the low pass filter to the signal, wherein the parasitic fringes are generated at least by presence of linearly polarized parasitic reflections, and wherein the linearly polarized parasitic reflections are caused by the optical beam which passes through a substrate of the biosensor and is then reflected from a top surface of the biosensor.
2 more elements
Dependencies are inferred from the claim text.